<scp>d</scp> -lactate modulates M2 tumor-associated macrophages and remodels immunosuppressive tumor microenvironment for hepatocellular carcinoma

Han, Shulan; Bao, Xueying; Zou, Yifang; Wang, Lingzhi; Li, Yutong; Yang, Leilei; Liao, Anqi; Zhang, Xuemei; Jiang, Xin; Liang, Di; Dai, Yun; Zheng, Qing‐Chuan; Yu, Zhuo; Guo, Jianfeng

doi:10.1126/sciadv.adg2697

Public

d -lactate modulates M2 tumor-associated macrophages and remodels immunosuppressive tumor microenvironment for hepatocellular carcinoma

Published in Science Advances • Jul 19, 2023

Authors:

Shulan Han

Xueying Bao

Yifang Zou

Abstract

The polarization of tumor-associated macrophages (TAMs) from M2 to M1 phenotype demonstrates great potential for remodeling the immunosuppressive tumor microenvironment (TME) of hepatocellular carcinoma (HCC). d -lactate (DL; a gut microbiome metabolite) acts as an endogenous immunomodulatory agent ...

Subject

Tumor microenvironment

Cancer research

Hepatocellular carcinoma

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!