Ketolysis drives CD8<sup>+</sup> T cell effector function through effects on histone acetylation.

KM, Luda; J, Longo; SM, Kitchen-Goosen; LR, Duimstra; EH, Ma; MJ, Watson; BM, Oswald; Z, Fu; Z, Madaj; A, Kupai; BM, Dickson; LM, DeCamp; MS, Dahabieh; SE, Compton; R, Teis; I, Kaymak; KH, Lau; DP, Kelly; P, Puchalska; KS, Williams; CM, Krawczyk; D, Lévesque; FM, Boisvert; RD, Sheldon; SB, Rothbart; PA, Crawford; RG, Jones

doi:10.1016/j.immuni.2023.07.002

Public

Ketolysis drives CD8+ T cell effector function through effects on histone acetylation.

Shared by NobleBlocks on Jul 28, 2023 • 12:00 AM UTC

Authors:

Luda KM

Longo J

Kitchen-Goosen SM

Abstract

Environmental nutrient availability influences T cell metabolism, impacting T cell function and shaping immune outcomes. Here, we identified ketone bodies (KBs)-including β-hydroxybutyrate (βOHB) and acetoacetate (AcAc)-as essential fuels supporting CD8+ T cell metabolism and effector function. βOHB...

Subject

Metabolism

TCA cycle

Effector function

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