Ketolysis drives CD8+ T cell effector function through effects on histone acetylation

M. Luda, Katarzyna; Longo, Joseph; M. Kitchen-Goosen, Susan; R. Duimstra, Lauren; Eric, H.; J. Watson, McLane; M. Oswald, Brandon; Fu, Zhen; Madaj, Zachary; Kupai, Ariana; M. Dickson, Bradley; M. DeCamp, Lisa; S. Dahabieh, Michael; E. Compton, Shelby; Teis, Robert; Kaymak, Irem; H. Lau, Kin; P. Kelly, Daniel; Puchalska, Patrycja; S. Williams, Kelsey; M. Krawczyk, Connie; Lévesque, Dominique; Boisvert, François‐Michel; D. Sheldon, Ryan; B. Rothbart, Scott; A. Crawford, Peter; G. Jones, Russell

doi:10.1016/j.immuni.2023.07.002

Public

Ketolysis drives CD8+ T cell effector function through effects on histone acetylation

Published in Immunity • Jul 28, 2023

Authors:

Katarzyna M. Luda

Joseph Longo

Susan M. Kitchen-Goosen

Abstract

Environmental nutrient availability influences T cell metabolism, impacting T cell function and shaping immune outcomes. Here, we identified ketone bodies (KBs)—including β-hydroxybutyrate (βOHB) and acetoacetate (AcAc)—as essential fuels supporting CD8 + T cell metabolism and effector function. βOH...

Subject

Acetylation

Effector

Biology

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