Progressive loss of conserved spike protein neutralizing antibody sites in Omicron sublineages is balanced by preserved T cell immunity

Muik, Alexander; Gaby Lui, Bonny; Quandt, Jasmin; Diao, Huitian; Fu, Yunguan; Bacher, Maren; Gordon, Jessica; Toker, Aras; Grosser, Jessica; Ozhelvaci, Orkun; Grikscheit, Katharina; Hoehl, Sebastian; Kohmer, Niko; Lustig, Yaniv; Regev‐Yochay, Gili; Ciesek, Sandra; Beguir, Karim; Poran, Asaf; Vogler, Isabel; Türeci, Özlem; Şahin, Uğur

doi:10.1016/j.celrep.2023.112888

Public

Progressive loss of conserved spike protein neutralizing antibody sites in Omicron sublineages is balanced by preserved T cell immunity

Published in Cell Reports • Jul 31, 2023

Authors:

Alexander Muik

Bonny Gaby Lui

Jasmin Quandt

Abstract

Evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant has led to the emergence of sublineages with different patterns of neutralizing antibody evasion. We report that Omicron BA.4/BA.5 breakthrough infection of individuals immunized with SARS-CoV-2 wild-type-s...

Subject

Neutralization

Epitope

Virology

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