<i>CXCL9:SPP1</i> macrophage polarity identifies a network of cellular programs that control human cancers

Bill, Ruben; Wirapati, Pratyaksha; Messemaker, Marius; Roh, Whijae; Zitti, Béatrice; Duval, Florent; Kiss, Máté; Chul Park, Jong; M. Saal, Talia; Hoelzl, Jan; Tarussio, David; Benedetti, Fabrizio; Tissot, Stéphanie; E. Kandalaft, Lana; Varrone, Marco; Ciriello, Giovanni; McKee, Thomas; Monnier, Yan; Mermod, Maxime; M. Blaum, Emily; Gushterova, Irena; Gonye, Anna; Hacohen, Nir; Getz, Gad; R. Mempel, Thorsten; M. Klein, Allon; Weissleder, Ralph; C. Faquin, William; M. Sadow, Peter; T. Lin, Derrick; I. Pai, Sara; Sade-Feldman, Moshe; J. Pittet, Mikaël

doi:10.1126/science.ade2292

Public

CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers

Published in Science • Aug 3, 2023

Authors:

Ruben Bill

Pratyaksha Wirapati

Marius Messemaker

Abstract

Tumor microenvironments (TMEs) influence cancer progression but are complex and often differ between patients. Considering that microenvironment variations may reveal rules governing intratumoral cellular programs and disease outcome, we focused on tumor-to-tumor variation to examine 52 head and nec...

Subject

Polarity (international relations)

Macrophage

Tumor microenvironment

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