A mosaic adeno-associated virus vector as a versatile tool that exhibits high levels of transgene expression and neuron specificity in primate brain

Kimura, Kei; Nagai, Yuji; Hatanaka, Gaku; Fang, Yang; Tanabe, Soshi; Zheng, Andi; Fujiwara, Maki; Nakano, Mayuko; Hori, Yukiko; Takeuchi, Ryosuke; Inagaki, Mikio; Minamimoto, Takafumi; Fujita, Ichiro; Inoue, Ken‐ichi; Takada, Masahiko

doi:10.1038/s41467-023-40436-1

Public

A mosaic adeno-associated virus vector as a versatile tool that exhibits high levels of transgene expression and neuron specificity in primate brain

Published in Nature Communications • Aug 8, 2023

Authors:

Kei Kimura

Yuji Nagai

Gaku Hatanaka

Abstract

Recent emphasis has been placed on gene transduction mediated through recombinant adeno-associated virus (AAV) vector to manipulate activity of neurons and their circuitry in the primate brain. In the present study, we created a novel vector of which capsid was composed of capsid proteins derived fr...

Subject

Transgene

Vector (molecular biology)

Adeno-associated virus

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