Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets

Hua Zhao, Jing; Stacey, David; Eriksson, Niclas; Macdonald-Dunlop, Erin; K. Hedman, Åsa; Kalnapenkis, Anette; Enroth, Stefan; Cozzetto, Domenico; Digby‐Bell, Jonathan; Marten, Jonathan; Folkersen, Lasse; Herder, Christian; Jönsson, Lina; E. Bergen, Sarah; Gieger, Christian; J. Needham, Elise; Surendran, Praveen; Metspalu, Andres; Milani, Lili; Mägi, Reedik; Nelis, Mari; Hudjašov, Georgi; S. Paul, Dirk; Polašek, Ozren; Thorand, Barbara; Grallert, Harald; Roden, Michael; Võsa, Urmo; Esko, Tõnu; Hayward, Caroline; Johansson, Åsa; Gyllensten, Ulf; Powell, Nick; Hansson, Oskar; Mattsson, Niklas; K. Joshi, Peter; Danesh, John; Padyukov, Leonid; Klareskog, Lars; Landén, Mikael; F. Wilson, James; Siegbahn, Agneta; Wallentin, Lars; Mälarstig, Anders; S. Butterworth, Adam; E. Peters, James

doi:10.1038/s41590-023-01588-w

Public

Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets

Published in Nature Immunology • Aug 10, 2023

Authors:

Jing Hua Zhao

David Stacey

Niclas Eriksson

Abstract

Circulating proteins have important functions in inflammation and a broad range of diseases. To identify genetic influences on inflammation-related proteins, we conducted a genome-wide protein quantitative trait locus (pQTL) study of 91 plasma proteins measured using the Olink Target platform in 14,...

Subject

Immune system

Disease

Immunology

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