The diversified role of mitochondria in ferroptosis in cancer

Liu, Yue; Lu, Shi-Ping; Wu, Lei‐Lei; Yang, Liang; Yang, Lixue; Wang, Jinghan; Yang, Lixue; Wang, Jinghan

doi:10.1038/s41419-023-06045-y

Public

The diversified role of mitochondria in ferroptosis in cancer

Published in Cell Death and Disease • Aug 14, 2023

Authors:

Yue Liu

Shi-Ping Lu

Lei‐Lei Wu

Abstract

Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation, and it has been studied extensively since its discovery in 2012. Induced by iron overload and ROS accumulation, ferroptosis is modulated by various cellular metabolic and signaling pathways. The GSH-GPX4 path...

Subject

Mitochondrion

Cell biology

Mitophagy

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