Whole-genome mapping of APOBEC mutagenesis in metastatic urothelial carcinoma identifies driver hotspot mutations and a novel mutational signature

J. A., Nakauma-Gonzalez,; M., Rijnders,; M. T. W., Noordsij,; J. W. M., Martens,; der Veldt, A., van; M. P., Lolkema,; J. L., Boormans,; de Werken, H. J. G., van

doi:10.1101/2023.08.09.23293865

Public

Whole-genome mapping of APOBEC mutagenesis in metastatic urothelial carcinoma identifies driver hotspot mutations and a novel mutational signature

Shared by NobleBlocks on Aug 13, 2023 • 12:00 AM UTC

Authors:

Nakauma-Gonzalez, J. A.

Rijnders, M.

Noordsij, M. T. W.

Abstract

APOBEC enzymes mutate specific DNA sequences and hairpin-loop structures, challenging the distinction between passenger and driver hotspot mutations. Here, we characterized 115 whole-genomes of metastatic urothelial carcinoma (mUC) to identify APOBEC mutagenic hotspot drivers. APOBEC-associated muta...

Subject

oncology

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