TUG1-mediated R-loop resolution at microsatellite loci as a prerequisite for cancer cell proliferation

Suzuki, Miho; Iijima, Kenta; Ogami, Koichi; Shinjo, Keiko; Murofushi, Yoshiteru; Xie, Jingqi; Wang, Xuebing; Kitano, Yotaro; Mamiya, A.; Kibe, Yuji; Nishimura, Tatsunori; Ohka, Fumiharu; Saito, Ryuta; Sato, Shinya; Kobayashi, Junya; Yao, Ryoji; Miyata, Kanjiro; Kataoka, Kazunori; Suzuki, Hiroshi; Kondo, Yutaka

doi:10.1038/s41467-023-40243-8

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TUG1-mediated R-loop resolution at microsatellite loci as a prerequisite for cancer cell proliferation

Published in Nature Communications • Aug 22, 2023

Authors:

Miho Suzuki

Kenta Iijima

Koichi Ogami

Abstract

Oncogene-induced DNA replication stress (RS) and consequent pathogenic R-loop formation are known to impede S phase progression. Nonetheless, cancer cells continuously proliferate under such high-stressed conditions through incompletely understood mechanisms. Here, we report taurine upregulated gene...

Subject

Biology

Downregulation and upregulation

Cancer cell

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