Atezolizumab Combined With Bevacizumab and Platinum-Based Therapy for Platinum-Sensitive Ovarian Cancer: Placebo-Controlled Randomized Phase III ATALANTE/ENGOT-ov29 Trial

Kurtz, Jean‐Emmanuel; Pujade-Lauraine, Éric; Oaknin, Ana; Belin, Lisa; Leitner, Katharina; Cibula, David; Denys, Hannelore; Rosengarten, Ora; Rodrigues, Manuel; de Gregorio, Nikolaus; Martínez, Jerónimo; Petru, Edgar; Kocián, Roman; Vergote, Ignace; Pautier, Patricia; Schmalfeldt, Barbara; Gaba, Lydia; Polterauer, Stephan; Mouret‐Reynier, Marie‐Ange; Sehouli, Jalid; Churruca, Cristina; Selle, Frédèric; Joly, Florence; D’Hondt, Véronique; Bultot-Boissier, Émilie; Lebreton, Coriolan; Lotz, Jean‐Pierre; Largillier, Rémy; Heudel, Pierre‐Etienne; Heitz, Florian; behalf of the ATALANTE/ENGOT-ov29 Investigators, on; Kurtz, Jean‐Emmanuel; Abadie‐Lacourtoisie, Sophie; Abdeddaim, Cyril; Alexandre, J.; Augereau, P.; Avenin, D.; Azémar, M.; Baba-Hamed, Nabil; Bally, Olivia; Barrière, Jérôme; Bazán, Fernando; Berton, Dominique; Bonichon-Lamichhane, Nathalie; Bonnin, Nathalie; Boughalem, Elouen; Boustany Grenier, R.; Brachet, Pierre-Emmanuel; Brocard, Fabien; Bultot-Boissier, Émilie; Cappiello-Bataller, Maria; Castanie, H.; Chaigneau, L.; Chakiba, Camille; Chocteau-Bouju, Dorothée; Combe, Pierre; Comte, Aurélie; Coquan, Elodie; Costan, Cristina; Cottu, P.; Crouzet, L.; Curé, H.; Dauba, Jérôme; Dawood, Hussain; De Cock, Laure; De La Motte Rouge, T.; Debelleix, C.; Delbaldo, Catherine; Demarchi, Martin; Deslandres, Marion; Despax, Raymond; D’Hondt, Véronique; Françoise DILLIES-LEGRAIN, Anne; Donnadieu, A; Dubot, C.; Marc Extra, Jean; Fabbro, Michel; Falandry, Claire; Fiteni, F.; Floquet, Anne; Follana, Philippe; Frenel, Jean‐Sébastien; Freyer, G.; Garbay-Decoopman, D.; Gavoille, Céline; Girre, V.; Gladieff, Laurence; Goldwasser, F.; Gratet, Alain; Grenier, Jean‐Christophe; Hardy‐Bessard, Anne‐Claire; Heudel, Pierre‐Etienne; Joly, Florence; Jouinot, A.; Kalbacher, Emilie; Kaminsky, Marie‐Christine; Lancry-Lecomte, Laurence; Largillier, R.; Le Du, Fanny; Léary, Alexandra; Lebreton, Coriolan; Lefeuvre-Plesse, C.; Lesoin, Anne; L'Haridon, T.; Long, Jérôme; Lortholary, Alain; Lotz, Jean‐Pierre; Mansi, Luigi; Martin-Babau, J.; Martinez, Mathilde; Medioni, J.; Meriaux, Émeline; Meunier, Juliette; Moise, Laura; Moulin, J.-F.; Mouret‐Reynier, Marie‐Ange; Mousseau, M.; Pautier, Patricia; Peron, J.; Perrin, Christophe; Petit, Thierry; Petran, Daniela; Priou, Frank; Provansal, Magali; Raban, Nadia; Ray‐Coquard, Isabelle; Régnault de la Mothe, P.; C. Riedl, Christopher; Rodrigues, Manuel; Roemer-Bécuwe, C.; Sabatier, R.; Savinelli, Francesco; Sebbag, Clara; Selle, Frédèric; Soulié, P; Spaëth, D.; Sverdlin, Robert; Timar-David, M.; Trédan, Olivier; Tresca, Patricia; Trillet-Lenoir, V.; Valentin, Thomas; Vano, Yann; You, Benoît; Heitz, Florian; Bronger, Holger; Buderath, Paul; de Gregorio, Nikolaus; Fehm, Tanja; Grischke, Eva‐Maria; Gropp-Meier, M.; Hartkopf, A.; Jackisch, C.; Koegel, M.; Müller, Andreas; Park‐Simon, Tjoung‐Won; B. Runnebaum, Ingo; Schochter, Fabienne; Schmalfeldt, Barbara; Schnappauf, Benjamin; Sehouli, Jalid; Trillsch, Fabian; Wimberger, Pauline; Oaknin, Ana; Alarcón, Jesús; Alonso, Sonsoles; Herrero, Ana; Barretina-Ginesta, Maria-Pilar; Casado, Antonio; Churruca, Cristina; Fernández, Iria; Gaba, Lydia; García-Donás, Jesús; González, Sergio; Marquina, Gloria; Martínez-García, Jerónimo; Redondo, Andrés; Vicente, Diego; Marth, Christian; Aust, Stefanie; Petru, Edgar; Reinthaller, Alexander; Schauer, Christian; Cibula, David; Vergote, Ignace; Altıntaş, Sevilay; Denys, Hannelore; Van Nieuwenhuysen, Els; Rosengarten, Ora

doi:10.1200/jco.23.00529

Public

Atezolizumab Combined With Bevacizumab and Platinum-Based Therapy for Platinum-Sensitive Ovarian Cancer: Placebo-Controlled Randomized Phase III ATALANTE/ENGOT-ov29 Trial

Published in Journal of Clinical Oncology • Aug 29, 2023

Authors:

Jean‐Emmanuel Kurtz

Éric Pujade-Lauraine

Ana Oaknin

Abstract

PURPOSE Platinum-based doublets with concurrent and maintenance bevacizumab are standard therapy for ovarian cancer (OC) relapsing after a platinum-free interval (PFI) >6 months. Immunotherapy may be synergistic with bevacizumab and chemotherapy. PATIENTS AND METHODS ATALANTE/ENGOT-ov29 (ClinicalTri...

Subject

Medicine

Atezolizumab

Bevacizumab

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