Impact of androgen receptor alterations on cell‐free DNA genomic profiling on survival outcomes in metastatic castration‐resistant prostate cancer

Tripathi, Nishita; Mathew Thomas, Vinay; Sayegh, Nicolas; Gebrael, Georges; Chigarira, Beverly; Jo, Yeonjung; Li, Haoran; Kant Sahu, Kamal; Nussenzveig, Roberto; Nordblad, Blake; Swami, Umang; Agarwal, Neeraj; L. Maughan, Benjamin

doi:10.1002/pros.24618

Public

Impact of androgen receptor alterations on cell‐free DNA genomic profiling on survival outcomes in metastatic castration‐resistant prostate cancer

Published in The Prostate • Aug 29, 2023

Authors:

Nishita Tripathi

Vinay Mathew Thomas

Nicolas Sayegh

Abstract

Abstract Background Androgen receptor (AR) gene alterations, as detected by circulating tumor cell‐free DNA (cfDNA) genomic profiling, have been shown to emerge after a variable duration of androgen signaling inhibition. AR alterations were associated with inferior outcomes on treatment with androge...

Subject

Androgen receptor

Medicine

Prostate cancer

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