A mutant fitness compendium in Bifidobacteria reveals molecular determinants of colonization and host-microbe interactions

L. Shiver, Anthony; Sun, Jiawei; N. Culver, Rebecca; Violette, Arvie; Wynter, Charles; Nieckarz, Marta; Paula Mattiello, Samara; Kaur Sekhon, Prabhjot; Friess, Lisa; K. Carlson, Hans; Wong, Daniel; K. Higginbottom, Steven; Weglarz, Meredith; Wang, Weigao; D. Knapp, Benjamin; R. Guiberson, Emma; M. Sánchez, Juan; Huang, Po‐Hsun; Alonso Gaona-García, Paulo; Buie, Cullen; H. Good, Benjamin; C. DeFelice, Brian; Cava, Felipe; Scaria, Joy; L. Sonnenburg, Justin; van Sinderen, Douwe; M. Deutschbauer, Adam; Casey Huang, Kerwyn

doi:10.1101/2023.08.29.555234

Public

A mutant fitness compendium in Bifidobacteria reveals molecular determinants of colonization and host-microbe interactions

Published in bioRxiv (Cold Spring Harbor Laboratory) • Aug 29, 2023

Authors:

Anthony L. Shiver

Jiawei Sun

Rebecca N. Culver

Abstract

Abstract Bifidobacteria commonly represent a dominant constituent of human gut microbiomes during infancy, influencing nutrition, immune development, and resistance to infection. Despite interest as a probiotic therapy, predicting the nutritional requirements and health-promoting effects of Bifidoba...

Subject

Biology

Colonization

Compendium

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