GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture

Stevelink, Remi; Campbell, Ciarán; Chen, Siwei; Abou‐Khalil, Bassel; M. Adesoji, Oluyomi; Afawi, Zaid; Amadori, Elisabetta; Anderson, Alison; Anderson, Joseph; M. Andrade, Danielle; Annesi, Grazia; Auce, Pauls; Avberšek, Andreja; Bahlo, Melanie; D. Baker, Mark; Balagura, Ganna; Balestrini, Simona; Barba, Carmen; Barboza, Karen; Bartoloméi, Fabrice; Bast, Thomas; Baum, Larry; Baumgartner, Tobias; Baykan, Betül; Bebek, Nerses; J. Becker, Albert; Becker, Felicitas; A. Bennett, Caitlin; Berghuis, Bianca; F. Berkovic, Samuel; Beydoun, Ahmad; Bianchini, Claudia; Bisulli, Francesca; Blatt, Ilan; Reddy Bobbili, Dheeraj; Borggraefe, Ingo; M. Boßelmann, Christian; Braatz, Vera; P. Bradfield, Jonathan; Brockmann, Knut; C. Brody, Lawrence; J. Buono, Russell; M. Busch, Robyn; Çağlayan, Hande; Campbell, Ellen; Canafoglia, Laura; Canavati, Christina; D. Cascino, Gregory; Castellotti, Barbara; B. Catarino, Claudia; L. Cavalleri, Gianpiero; Cerrato, Felecia; Chassoux, Francine; S. Cherny, Stacey; Cheung, Ching‐Lung; Chinthapalli, Krishna; Chou, I‐Jun; Chung, Seo‐Kyung; Churchhouse, Claire; O. Clark, Peggy; J. Cole, Andrew; Compston, Alastair; Coppola, Antonietta; Cosico, Mahgenn; Cossette, Patrick; Craig, John; Cusick, Caroline; J. Daly, Mark; K. Davis, Lea; de Haan, Gerrit‐Jan; Delanty, Norman; Depondt, Chantal; Derambure, Philippe; Devinsky, Orrin; Di Vito, Lidia; Dlugos, Dennis; Doccini, Viola; P. Doherty, Colin; El-Naggar, Hany; E. Elger, Christian; A. Ellis, Colin; G. Eriksson, Johan; Faucon, Annika; Anne Feng, Yen‐Chen; Ferguson, Lisa; N. Ferraro, Thomas; Ferri, Lorenzo; Feucht, Martha; P. Fitzgerald, Mark; Fonferko‐Shadrach, Beata; Fortunato, Francesco; Franceschetti, Silvana; Franke, Andre; A. French, Jacqueline; Freri, Elena; Gagliardi, Monica; Gambardella, Antonio; B. Geller, Eric; Giangregorio, Tania; Gjerstad, Leif; A. Glauser, Tracy; M. Goldberg, Ethan; Goldman, Alicia; Granata, Tiziana; A. Greenberg, David; Guerrini, Renzo; Gupta, Namrata; F. Haas, Kevin; Håkonarson, Håkon; Hallmann, Kerstin; Hassanin, Emadeldin; Hegde, Manu; L. Heinzen, Erin; Helbig, Ingo; Hengsbach, Christian; Heyne, Henrike; Hirose, Shinichi; Hirsch, Édouard; Hjalgrim, Helle; P. Howrigan, Daniel; Hucks, Donald; Hung, Po‐Cheng; Iacomino, Michele; Imbach, Lukas; Inoue, Yushi; Ishii, Atsushi; Jamnadas-Khoda, Jennifer; Jehi, Lara; R. Johnson, Michael; Kälviäinen, Reetta; Kamatani, Yoichiro; Kanaan, Moien; Kanai, Masahiro; Kantanen, Anne-Mari; Kara, Bülent; M. Kariuki, Symon; Kasperavičiūtė, Dalia; Kasteleijn‐Nolst Trenité, Dorothée; Kato, Mitsuhiro; Kegele, Josua; Kesim, Yeşim; K. Zgheib, Nathalie; King, Chontelle; E. Kirsch, Heidi; Martin Klein, Karl; Kluger, Gerhard; Knake, Susanne; C. Knowlton, Robert; P.C. Koeleman, Bobby; D. Korczyn, Amos; Koupparis, Andreas; Kousiappa, Ioanna; Krause, Roland; Krenn, Martin; Krestel, Heinz; Krey, Ilona; S. Kunz, Wolfram; Kurki, Mitja; Kurlemann, Gerhard; Kuzniecky, Ruben; Kwan, Patrick; Labate, Angelo; Lacey, Austin; Lal, Dennis; Landoulsi, Zied; Lau, YL; Lauxmann, Stephen; L. Leech, Stephanie; Lehesjoki, Anna‐Elina; R. Lemke, Johannes; Lerche, Holger; Lesca, Gaëtan; Leu, Costin; Lewin, Naomi; Lewis‐Smith, David; Hoi‐Yee Li, Gloria; S. Li, Qingqin; Licchetta, Laura; Lin, Kuang-Lin; Lindhout, Dick; Linnankivi, Tarja; Lopes‐Cendes, Íscia; H. Lowenstein, Daniel; H. T. Lui, Colin; Madia, Francesca; H. Magnússon, Sigurður; G Marson, Anthony; May, Patrick; M. McGraw, Christopher; Mei, Davide; L. Mills, James; Minardi, Raffaella; Mirza, Nasir; S. Møller, Rikke; M. Molloy, Anne; Montomoli, Martino; Mostacci, Barbara; Muccioli, Lorenzo; Muhle, Hiltrud; Müller‐Schlüter, Karen; Najm, Imad; Nasreddine, Wassim; M. Neale, Benjamin; A. Neubauer, Bernd; R. Newton, Charles; M. Nöthen, Markus; Nothnagel, Michael; Nürnberg, Peter; J. O’Brien, Terence; Okada, Yukinori; Ólafsson, Elías; Oliver, Karen; Özkara, Çiğdem; Palotie, Aarno; Pangilinan, Faith; Papacostas, Savvas; Parrini, Elena; N. Pato, Carlos; T. Pato, Michele; Pendziwiat, Manuela; Petrovski, Slavé; Owen Pickrell, William; Pinsky, Rebecca; Pippucci, Tommaso; Poduri, Annapurna; Pondrelli, Federica; Powell, Robert; Privitera, Michael; Rademacher, Annika; A. Radtke, Rodney; Ragona, Francesca; Rau, Sarah; I. Rees, Mark; M. Regan, Brigid; S. Reif, Philipp; Rhelms, Sylvain; Riva, Antonella; Rosenow, Felix; Ryvlin, Philippe; Saarela, Anni; G. Sadleir, Lynette; W. Sander, Josemir; Sander, Thomas; Scala, Marcello; Scattergood, Theresa; C. Schachter, Steven; J. Schankin, Christoph; E. Scheffer, Ingrid; Schmitz, Bettina; Schoch, Susanne; Schubert‐Bast, Susanne; Schulze‐Bonhage, Andreas; Scudieri, Paolo; C. Sham, Pak; Rosen Sheidley, Beth; J. Shih, Jerry; J. Sills, Graeme; M. Sisodiya, Sanjay; C. Smith, Michael; E M Smith, Phil; C. M. Sonsma, Anja; Speed, Doug; R. Sperling, Michael; Stefánsson, Hreinn; Stefansson, Kári; J. Steinhoff, Bernhard; Stephani, Ulrich; C. Stewart, William; Stipa, Carlotta; Striano, Pasquale; Stroink, Hans; Strzelczyk, Adam; Surges, Rainer; Suzuki, Toshimitsu; Meng Tan, K.; Taneja, R.; A. Tanteles, George; Taubøll, Erik; Lin Thio, Liu; Neil Thomas, G.; H. Thomas, Rhys; Timonen, Oskari; Tinuper, Paolo; Todaro, Marian; Topaloğlu, Pınar; Tozzi, Rossana; Tsai, Meng‐Han; Tumiene, Biruté; Türkdoğan, Dilşad; Unnsteinsdóttir, Unnur; Utkus, Algirdas; Vaidiswaran, Priya; Valton, Luc; van Baalen, Andreas; Vetro, Annalisa; P.G. Vining, Eileen; Visscher, Frank; von Brauchitsch, Sophie; von Wrede, Randi; G. Wagner, Ryan; Weber, Yvonne; Weckhuysen, Sarah; Weisenberg, Judith; Weller, Michael; Widdess‐Walsh, Peter; Wolff, Markus; Wolking, Stefan; Wu, David; Yamakawa, Kazuhiro; Yang, Wanling; Yapıcı, Zühal; Yücesan, Emrah; Zagaglia, Sara; Zahnert, Felix; Zara, Federico; Zhou, Wei; Zimprich, Fritz; Zsurka, Gábor; Zulfiqar Ali, Quratulain

doi:10.1038/s41588-023-01485-w

Public

GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture

Published in Nature Genetics • Aug 31, 2023

Authors:

Remi Stevelink

Ciarán Campbell

Siwei Chen

Abstract

Epilepsy is a highly heritable disorder affecting over 50 million people worldwide, of which about one-third are resistant to current treatments. Here we report a multi-ancestry genome-wide association study including 29,944 cases, stratified into three broad categories and seven subtypes of epileps...

Subject

Genetic architecture

Genome-wide association study

Biology

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