Safety and efficacy of tenecteplase versus alteplase in stroke patients with carotid tandem lesions: Results from the AcT trial

Bala, Fouzi; Almekhlafi, Mohammed; Singh, Nishita; Alhabli, Ibrahim; Ademola, Ayoola; B. Coutts, Shelagh; Deschaintre, Yan; Khosravani, Houman; Appireddy, Ramana; Moreau, F.; Phillips, Stephen; Gubitz, Gord; Tkach, Aleksander; Catanese, Luciana; Dowlatshahi, Dar; Medvedev, George; Mandzia, Jennifer; Pikula, Aleksandra; Shankar, Jay; Williams, Heather; S. Field, Thalia; Manosalva, Alejandro; Siddiqui, Muzaffar; Zafar, Atif; Imoukhoude, Oje; Hunter, Gary; Benali, Faysal; Horn, MacKenzie; D. Hill, Michael; Shamy, Michel; T. Sajobi, Tolulope; Buck, Brian; H. Swartz, Richard; K. Menon, Bijoy; Y. Poppe, Alexandre

doi:10.1177/17474930231205208

Public

Safety and efficacy of tenecteplase versus alteplase in stroke patients with carotid tandem lesions: Results from the AcT trial

Published in International Journal of Stroke • Sep 20, 2023

Authors:

Fouzi Bala

Mohammed Almekhlafi

Nishita Singh

Abstract

BACKGROUND: Carotid tandem lesions ((TL) ⩾70% stenosis or occlusion) account for 15-20% of acute stroke with large vessel occlusion. AIMS: We investigated the safety and efficacy of intravenous tenecteplase (0.25 mg/kg) versus intravenous alteplase (0.9 mg/kg) in patients with carotid TL. METHODS: T...

Subject

Medicine

Tenecteplase

Thrombolysis

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