Rules and mechanisms governing G protein coupling selectivity of GPCRs

G protein-coupled receptors (GPCRs) convert extracellular stimuli into intracellular signaling by coupling to heterotrimeric G proteins of four classes: G i/o , G q , G s , and G 12/13 . However, our understanding of the G protein selectivity of GPCRs is incomplete. Here, we quantitatively measure t... View More