Plasma proteomic associations with genetics and health in the UK Biobank

B. Sun, Benjamin; Chiou, Joshua; Traylor, Matthew; Benner, Christian; Hsu, Yi-Hsiang; G. Richardson, Tom; Surendran, Praveen; Mahajan, Anubha; Robins, Chloe; G. Vasquez-Grinnell, Steven; Hou, Liping; M. Kvikstad, Erika; S. Burren, Oliver; Davitte, Jonathan; L. Ferber, Kyle; E. Gillies, Christopher; K. Hedman, Åsa; Hu, Sile; Lin, Tinchi; Mikkilineni, Rajesh; K. Pendergrass, Rion; Pickering, Corran; Prins, Bram; Baird, Denis; Chen, Chia-Yen; D. Ward, Lucas; M. Deaton, Aimee; Welsh, Samantha; M. Willis, Carissa; Lehner, Nick; Arnold, Matthias; A. Wörheide, Maria; Suhre, Karsten; Kastenmüller, Gabi; Sethi, Anurag; Cule, Madeleine; Raj, Anil; Human Genetics, Alnylam; Genomics Initiative, AstraZeneca; Biobank Team, Biogen; Myers Squibb, Bristol; Human Genetics, Genentech; Genomic Sciences, GlaxoSmithKline; Integrative Biology, Pfizer; Analytics of Janssen Data Sciences, Population; Genetics Center, Regeneron; Ming Kang, Hyun; Burkitt-Gray, Lucy; Melamud, Eugene; Helen Black, Mary; B. Fauman, Eric; M. M. Howson, Joanna; Min Kang, Hyun; I. McCarthy, Mark; Nioi, Paul; Petrovski, Slavé; A. Scott, Robert; N. Smith, Erin; Szalma, Sándor; M. Waterworth, Dawn; J. Mitnaul, Lyndon; D. Szustakowski, Joseph; W. Gibson, Bradford; R. Miller, Melissa; D. Whelan, Christopher

doi:10.1038/s41586-023-06592-6

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Plasma proteomic associations with genetics and health in the UK Biobank

Shared by NobleBlocks on Oct 4, 2023 • 12:00 AM UTC

Authors:

Benjamin B. Sun

Joshua Chiou

Matthew Traylor

Abstract

Abstract The Pharma Proteomics Project is a precompetitive biopharmaceutical consortium characterizing the plasma proteomic profiles of 54,219 UK Biobank participants. Here we provide a detailed summary of this initiative, including technical and biological validations, insights into proteomic disea...

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