Effect of Time to Thrombolysis on Clinical Outcomes in Patients With Acute Ischemic Stroke Treated With Tenecteplase Compared to Alteplase: Analysis From the AcT Randomized Controlled Trial

Singh, Nishita; Almekhlafi, Mohammed; Bala, Fouzi; Ademola, Ayoola; B. Coutts, Shelagh; Deschaintre, Yan; Khosravani, Houman; Buck, Brian; Appireddy, Ramana; Moreau, F.; Gubitz, Gord; Tkach, Aleksander; Catanese, Luciana; Dowlatshahi, Dar; Medvedev, George; Mandzia, Jennifer; Pikula, Aleksandra; Shankar, Jai; Ghrooda, Esseeddeegg; Y. Poppe, Alexandre; Williams, Heather; S. Field, Thalia; Manosalva, Alejandro; Siddiqui, Muzaffar; Zafar, Atif; Imoukhoude, Oje; Hunter, Gary; Shamy, Michel; M. Demchuk, Andrew; Claggett, Brian; D. Hill, Michael; T. Sajobi, Tolulope; H. Swartz, Richard; K. Menon, Bijoy

doi:10.1161/strokeaha.123.044267

Public

Effect of Time to Thrombolysis on Clinical Outcomes in Patients With Acute Ischemic Stroke Treated With Tenecteplase Compared to Alteplase: Analysis From the AcT Randomized Controlled Trial

Published in Stroke • Oct 6, 2023

Authors:

Nishita Singh

Mohammed Almekhlafi

Fouzi Bala

Abstract

BACKGROUND: The AcT (Alteplase Compared to Tenecteplase) randomized controlled trial showed that tenecteplase is noninferior to alteplase in treating patients with acute ischemic stroke within 4.5 hours of symptom onset. The effect of time to treatment on clinical outcomes with alteplase is well kno...

Subject

Tenecteplase

Medicine

Thrombolysis

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