Apoptotic stress causes mtDNA release during senescence and drives the SASP

Victorelli, Stella; Salmonowicz, Hanna; Chapman, James; Martini, Hélène; Grazia Vizioli, Maria; S. Riley, Joel; Cloix, Catherine; Hall-Younger, Ella; Machado Espíndola‐Netto, Jair; Jurk, Diana; B. Lagnado, Anthony; Sales Gomez, Lilian; N. Farr, Joshua; Saul, Dominik; Reed, Rebecca; Kelly, George; Eppard, Madeline; C. Greaves, Laura; Dou, Zhixun; Pirius, Nicholas; Szczepanowska, Karolina; A. Porritt, Rebecca; Huang, Huijie; Y. Huang, Timothy; A. Mann, Derek; A. Masuda, Cláudio; Khosla, Sundeep; Dai, Haiming; H. Kaufmann, Scott; Zacharioudakis, Emmanouil; Gavathiotis, Evripidis; K. LeBrasseur, Nathan; Lei, Xue; G. Sainz, Alva; I. Korolchuk, Viktor; D. Adams, Peter; S. Shadel, Gerald; W. G. Tait, Stephen; F. Passos, João

doi:10.1038/s41586-023-06621-4

Public

Apoptotic stress causes mtDNA release during senescence and drives the SASP

Published in Nature • Oct 11, 2023

Authors:

Stella Victorelli

Hanna Salmonowicz

James Chapman

Abstract

Abstract Senescent cells drive age-related tissue dysfunction partially through the induction of a chronic senescence-associated secretory phenotype (SASP) 1 . Mitochondria are major regulators of the SASP; however, the underlying mechanisms have not been elucidated 2 . Mitochondria are often essent...

Subject

Senescence

Cell biology

Mitochondrion

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