Polyphyllin I induced ferroptosis to suppress the progression of hepatocellular carcinoma through activation of the mitochondrial dysfunction via Nrf2/HO-1/GPX4 axis

Yang, Renyi; Gao, Wenhui; Wang, Zhibing; Jian, Huiying; Lian, Peng; Peng, Lian; Yu, Xiaopeng; Xue, Peisen; Peng, Wei; Li, Kexiong; Zeng, Puhua

doi:10.1016/j.phymed.2023.155135

Public

Polyphyllin I induced ferroptosis to suppress the progression of hepatocellular carcinoma through activation of the mitochondrial dysfunction via Nrf2/HO-1/GPX4 axis

Published in Phytomedicine • Oct 12, 2023

Authors:

Renyi Yang

Wenhui Gao

Zhibing Wang

Abstract

BACKGROUND: Ferroptosis is an emerging iron-dependent programmed cell death mode characterized by lipid peroxidation and iron accumulation, closely associated with Hepatocellular Carcinoma (HCC) progression. Although the impact of Polyphyllin I (PPI), a prominent bioactive constituent derived from P...

Subject

Viability assay

Blot

Chemistry

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