Sustained antidepressant effect of ketamine through NMDAR trapping in the LHb

Ma, Shuangshuang; Chen, Min; Jiang, Yihao; Xiang, Xinkuan; Wang, Shiqi; Wu, Zuohang; Li, Shuo; Cui, Yihui; Wang, Junying; Zhu, Yanqing; Zhang, Yan; Ma, Huan; Duan, Shumin; Li, Haohong; Yang, Yan; J. Lingle, Christopher; Hu, Hailan

doi:10.1038/s41586-023-06624-1

Public

Sustained antidepressant effect of ketamine through NMDAR trapping in the LHb

Published in Nature • Oct 18, 2023

Authors:

Shuangshuang Ma

Min Chen

Yihao Jiang

Abstract

Abstract Ketamine, an N -methyl- d -aspartate receptor (NMDAR) antagonist 1 , has revolutionized the treatment of depression because of its potent, rapid and sustained antidepressant effects 2–4 . Although the elimination half-life of ketamine is only 13 min in mice 5 , its antidepressant activities...

Subject

Ketamine

NMDA receptor

Antidepressant

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