ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer

Su, Pingping; Mao, Xiaodan; Ma, Jincheng; Huang, Lixiang; Yu, Lirui; Tang, Shuting; Zhuang, Mingzhi; Lu, Zhonglei; Stefan Osafo, Kelvin; Ren, Yuan; Wang, Xinrui; Lin, Xite; Huang, Leyi; Huang, Xiaoli; Ioana Braicu, Elena; Sehouli, Jalid; Sun, Pengming

doi:10.1186/s13046-023-02834-7

Public

ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer

Published in Journal of Experimental & Clinical Cancer Research • Oct 20, 2023

Authors:

Pingping Su

Xiaodan Mao

Jincheng Ma

Abstract

BACKGROUND: Tumor cells can resist chemotherapy-induced pyroptosis through glycolytic reprogramming. Estrogen-related receptor alpha (ERRα) is a central regulator of cellular energy metabolism associated with poor cancer prognosis. Herein, we refine the oncogenic role of ERRα in the pyroptosis pathw...

Subject

Pyroptosis

Glycolysis

Endometrial cancer

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