Durvalumab Plus Carboplatin/Paclitaxel Followed by Maintenance Durvalumab With or Without Olaparib as First-Line Treatment for Advanced Endometrial Cancer: The Phase III DUO-E Trial

N. Westin, Shannon; N. Moore, Kathleen; Sook Chon, Hye; Lee, Jung‐Yun; Thomes Pepin, Jessica; Sundborg, Michael; Shai, Ayelet; de la Garza, Joseph; Nishio, Shin; A. Gold, Michael; Wang, Ke; McIntyre, Kristi; Tillmanns, Todd; V. Blank, Stephanie; Liu, Jihong; McCollum, Michael; Contreras Mejía, Fernando; Nishikawa, Tadaaki; P. Pennington, Kathryn; Novak, Zoltan; Cristina de Melo, Andréia; Sehouli, Jalid; Klasa-Mazurkiewicz, Dagmara; Papadimitriou, Christos; Gil-Martín, Marta; Brasiuniene, Birute; Donnelly, Conor; Michelle del Rosario, Paula; Liu, Xiaochun; Van Nieuwenhuysen, Els; Frentzas, Sophia; Kichendasse, Ganessan; Gao, Bo; Meniawy, Tarek; Mileshkin, Linda; Richardson, Gary; Roncolato, Felicia; Baurain, Jean‐François; Bourhaba, Maryam; Cuypere, Eveline; R. Debruyne, Philip; Denys, Hannelore; Forget, Frédéric; Honhon, Brigitte; Joosens, E.; Van Nieuwenhuysen, Els; da Costa Miranda, Vanessa; Cristina de Melo, Andréia; Daniel Guedes, Joao; Andreé Joseph de Pádua, Charles; Lazaretti, Nicolas; Martins Vieira, Carolina; Mattar, André; Neves Palmeiro, Daniela; Pimentel Oppermann Kussler, Christina; Emanuel Rubini Liedke, Pedro; Soares Nunes, João; Arima Tiscoski, Katsuki; Covens, Allan; De Guerké, Lara; Ghatage, Prafull; Gilbert, Lucy; Lau, Susie; M. Oza, Amit; Provencher, Diane; Touhami, Omar; Li, Congzhu; Wang, Danbo; Lou, Ge; Genhai, Zhu; Li, Guiling; Hong, Shi; Zheng, Hong; Hongwu, Wen; Liu, Jihong; Wang, Jing; Wang, Ke; Kui, Jiang; Li, Li; Li, Wang; Min, Hao; Zhou, Qi; Qinglei, Gao; Liao, Sihai; Songling, Zhang; Weidong, Zhao; Wu, Xiaohua; Wang, Wuliang; Yin, Rutie; Ying, Cheng; Zhang, Yu; Zhiqing, Liang; Contreras Mejía, Fernando; Luis Martín de Francisco Hernández, Ángel; Ortiz Lopez, Carolina; Javier Pacheco, Carlos; Luis Ramos Guette, Pedro; Rendon Pereira, Jaime; Rivera Diaz, Julian; Sánchez Villegas, Tomás; Pablo Suso, Juan; Antonio Torregroza Otero, Marco; Grišan, Karin; Vettus, Elen; Aktas, Bahriye; K. Egger, Eva; Krabisch, Petra; Müller, Andreas; Rom, Joachim; Sehouli, Jalid; Sperfeld, Antje; Wimberger, Pauline; Zorr, Andreas; Fountzilas, George; Karageorgopoulou, Sofia; Papadimitriou, Christos; Psyrri, Amanda; Zagour, Florai; K. L. Chan, Karen; Ming Ho, Wing; Csőszi, Tibor; Landherr, László; Novak, Zoltan; Pápai, Zsuzsanna; Póka, Ròbert; Sipőcz, István; Devinder, Paul; Goyal, Lovenish; Gupta, Sudeep; Naik, Radheshyam; Patil, Tushar; P. Somashekhar, S.; Bruchim, Ilan; Kovel, Svetlana; Leibovici, Anca; Rosengarten, Ora; Safra, Tamar; Yamagami, Wataru; Hamanishi, Junzo; Imai, Yuichi; Kado, Nobuhiro; Kamiura, Shoji; Kato, H.; Kondo, Eiji; Kudaka, Wataru; Matsumoto, Takashi; Mori, Masahiko; Nishikawa, Tadaaki; Nishio, Shin; Okamoto, Aikou; Yunokawa, Mayu; Sekine, Masayuki; Sumi, Toshiyuki; Takano, Hirokuni; Takehara, Kazuhiro; Brasiuniene, Birute; Inčiūra, Arturas; Jonuškienė, Goda; Elvis Cabrera Luviano, Jesus; Domínguez-Andrade, Adriana; Gerson-Cwilich, Raquel; Hernández Hernández, Carlos; Lopez Hernandez, Jesus; Luis Martinez Lira, Jose; Esteban Navarrete Aleman, Jaime; Reyes Contreras, Jessica; Rosas Camargo, Vanessa; Bednarek, Wiesława; Klasa-Mazurkiewicz, Dagmara; Kubiatowski, Tomasz; Potemski, Piotr; Sikorska, Magdalena; Chang, Suk‐Joon; Hee Hong, Sook; Kang, Sokbom; Kim, Byoung‐Gie; Kim, J.; Kim, Yong‐Man; Lee, Jung-Yun; Young Ryu, Sang; Jung Song, Yong; Kirtbaya, Dmitriy; M. Kreynina, Julya; Lisyanskaya, Alla; Makarova, Yulia; В. Орлова, Р.; Pirmagomedov, Albert; Saevets, Valeria; Safina, Sufia; Skopin, Pavel; Tyulyandina, Alexandra; Lei Lim, Sheow; Ngo Su Mien, Lynette; Peng, David; Tin Soh, Lay; Barretina-Ginesta, Maria-Pilar; Estévez-García, Purificación; Fernández Pérez, Isaura; Gálvez, Fernando; García García, Yolanda; Gil-Martín, Marta; Martínez, Jerónimo; Redondo-Sanchez, Andres; Anderson, Charles; Berman, Tara; V. Blank, Stephanie; E. Bradley, William; Burke, James; Cappuccini, Fabio; E. Carney, Michael; K. Chambers, Setsuko; Chen, Lee-may; Sook Chon, Hye; de la Garza, Joseph; DePasquale, Stephen; DiSilvestro, Paul; Edraki, Babak; Fleming, Evelyn; R. Fox, Jenny; A. Gold, Michael; E. Gordinier, Mary; S. Guy, Michael; M. Hartenbach, Ellen; Haygood, Chisten; Jordan, Scott; C. Kilgore, Larry; Kim, Young; A. Lucci, Joseph; McCollum, Michael; Mchale, Michael; McIntyre, Kristi; Messing, Mark; M. Miller, Eirwen; N. Moore, Kathleen; W. Moroney, John; Onstad, Michaela; M. Ortiz, Taylor; Ozair, Sobia; P. Pennington, Kathryn; S. Pfaendler, Krista; Priebe, Anna; Pustilnik, Terri; Resnick, Kimberly; G. Rose, Peter; Salinas, E.; Sharma, Sudarshan; Sobol, Urszula; T. Soliman, Pamela; Starks, David; Sundborg, Michael; Teplinsky, Eleonora; Thomes-Pepin, Jessica; Tillmanns, Todd; Warshal, David; N. Westin, Shannon; Woliver, Thomas

doi:10.1200/jco.23.02132

Public

Durvalumab Plus Carboplatin/Paclitaxel Followed by Maintenance Durvalumab With or Without Olaparib as First-Line Treatment for Advanced Endometrial Cancer: The Phase III DUO-E Trial

Published in Journal of Clinical Oncology • Oct 21, 2023

Authors:

Shannon N. Westin

Kathleen N. Moore

Hye Sook Chon

Abstract

PURPOSE Immunotherapy and chemotherapy combinations have shown activity in endometrial cancer, with greater benefit in mismatch repair (MMR)–deficient (dMMR) than MMR-proficient (pMMR) disease. Adding a poly(ADP-ribose) polymerase inhibitor may improve outcomes, especially in pMMR disease. METHODS T...

Subject

Durvalumab

Medicine

Olaparib

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