Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials

Rivellese, Felice; Nerviani, Alessandra; Giorli, Giovanni; Warren, Louise; Jaworska, Edyta; Bombardieri, Michele; Lewis, Myles; Humby, Frances; G. Pratt, Arthur; Filer, Andrew; Gendi, Nagui; Cauli, Alberto; Choy, Ernest; B. McInnes, Iain; Durez, Patrick; J Edwards, Christopher; H Buch, Maya; Gremese, Elisa; C. Taylor, Peter; Ng, Nora; D. Cañete, Juan; Raizada, Sabrina; D McKay, Neil; R. Jadon, Deepak; Paolo Sainaghi, Pier; Stratton, Richard; R. Ehrenstein, Michael; Ho, Pauline; Polido‐Pereira, Joaquim; Dasgupta, Bhaskar; Gorman, Claire; Galloway, James; Chinoy, Hector; van der Heijde, Désirée; Sasieni, Peter; Barton, Anne; Pitzalis, Costantino; S Zayat, Ahmed; Rita Marinho Machado, Ana; Cuervo, Andrea; Mahto, Arti; Çubuk, Cankut; Rawlings, Charlotte; H Mosanya, Chijioke; D. Buckley, Christopher; Holroyd, Chris; Maskall, Debbie; Carlucci, Francesco; Thorborn, Georgina; Tan, Gina; Lliso-Ribera, Gloria; Rizvi, Hasan; Peel, Joanna; Eurico Fonseca, João; D. Isaacs, John; Ramírez, Julio; Méric de Bellefon, Laurent; Fossati-Jimak, Liliane; Ng’endo Githinji, Mary; Congia, Mattia; L. Millar, Neal; Purkayastha, Nirupam; Celis, Raquel; Seth, Rakhi; Hands-Greenwood, Rebecca; Landewé, Robert; Perniola, Simone; Alivernini, Stefano; Marcia, Stefano; Marini, Stefano; Kelly, Stephen; C. Romão, Vasco

doi:10.1016/s2665-9913(23)00241-2

Public

Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials

Published in The Lancet Rheumatology • Oct 23, 2023

Authors:

Felice Rivellese

Alessandra Nerviani

Giovanni Giorli

Abstract

BACKGROUND: Despite highly effective targeted therapies for rheumatoid arthritis, about 40% of patients respond poorly, and predictive biomarkers for treatment choices are lacking. We did a biopsy-driven trial to compare the response to rituximab, etanercept, and tocilizumab in biologic-naive patien...

Subject

Medicine

Rheumatoid arthritis

Etanercept

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