Anaphylactic Reactions Caused by the Covid-19 Vaccine Comirnaty in Anti-PEG Hyperimmune Pigs: Implications for the Safety of mRNA-LNP-based Vaccines and Other PEGylated Nanopharmaceuticals

Szebeni, János; András Barta, Bálint; Radovits, Tamás; Balázs Dobos, Attila; Tibor Kozma, Gergely; Mészáros, Tamás; Berényi, Petra; Facskó, Réka; Fülöp, Tamás; Merkely, Béla

doi:10.22541/au.169898456.60178975/v1

Public

Anaphylactic Reactions Caused by the Covid-19 Vaccine Comirnaty in Anti-PEG Hyperimmune Pigs: Implications for the Safety of mRNA-LNP-based Vaccines and Other PEGylated Nanopharmaceuticals

Published • Nov 3, 2023

Authors:

János Szebeni

Bálint András Barta

Tamás Radovits

Abstract

Background: mRNA-containing, PEGylated Covid-19 vaccines can cause hypersensitivity reactions (HSRs), or rarely, life-threatening anaphylaxis in a small fraction of immunized people. A causal role of anti-PEG antibodies (Abs) has been proposed but not yet proven in a large animal model. Methods: Dom...

Subject

Medicine

Anaphylaxis

Immunology

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!