Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

Wang, Anqi; Shen, Jiayi; A Rodriguez, Alex; J. Saunders, Edward; Chen, Fei; Janivara, Rohini; F. Darst, Burcu; Sheng, Xin; Xu, Yili; Chou, Alisha; Benlloch, Sara; Dadaev, Tokhir; N. Brook, Mark; Plym, Anna; Sahimi, Ali; J. Hoffman, Thomas; Takahashi, Atushi; Matsuda, Koichi; Momozawa, Yukihide; Fujita, Masashi; Laisk, Triin; Figuerêdo, Jéssica; Muir, Kenneth; Ito, Shuji; Liu, Xiaoxi; Biobank Japan Project, The; Yamanashi, Yuji; Furukawa, Yoichi; Morisaki, Takayuki; Murakami, Yoshinori; Muto, Kaori; Nagai, Akiko; Obara, Wataru; Yamaji, Ken; Takahashi, Kazuhisa; Asai, Satoshi; Takahashi, Yasuo; Suzuki, Takao; Sinozaki, Nobuaki; Yamaguchi, Hiroki; Minami, Shiro; Murayama, Shigeo; Yoshimori, Kozo; Nagayama, Satoshi; Obata, Daisuke; Higashiyama, Masahiko; Masumoto, Akihide; Koretsune, Yukihiro; Uchio, Yuji; Kubo, Michiaki; Kamatani, Yoichiro; Lophatananon, Artitaya; Wan, Peggy; Andrews, Caroline; Lori, Adriana; Pal Choudhury, Parichoy; Schleutker, Johanna; L. J. Tammela, Teuvo; Sipeky, Csilla; Auvinen, Anssi; G. Giles, Graham; C. Southey, Melissa; J. MacInnis, Robert; Cybulski, Cezary; Wokołorczyk, Dominika; Lubiński, Jan; T. Rentsch, Christopher; Cho, Kelly; H. McMahon, Benjamin; E. Neal, David; L. Donovan, Jenny; C. Hamdy, Freddie; M. Martin, Richard; G. Nordestgaard, Børge; F. Nielsen, Sune; Weischer, Maren; E. Bojesen, Stig; Andreas Røder, Martin; Vincent Stroomberg, Hein; Batra, Jyotsna; K. Chambers, Suzanne; G. Horvath, Lisa; A. Clements, Judith; D. Tilley, Wayne; P. Risbridger, Gail; Grönberg, Henrik; Aly, Markus; Szulkin, Robert; Eklund, Martin; Nordström, Tobias; Pashayan, Nora; M. Dunning, Alison; Ghoussaini, Maya; C. Travis, Ruth; J. Key, Timothy; Ríboli, Elio; Y. Park, Jong; A. Sellers, Thomas; Lin, Hui‐Yi; Albanes, Demetrius; J. Weinstein, Stephanie; B. Cook, Michael; A. Mucci, Lorelei; L. Giovannucci, Edward; Lindström, Sara; Kraft, Peter; J. Hunter, David; L. Penney, Kathryn; Turman, Constance; M. Tangen, Catherine; J. Goodman, Phyllis; M. Thompson, Ian; J. Hamilton, Robert; E. Fleshner, Neil; Finelli, Antonio; Parent, Marie‐Élise; L. Stanford, Janet; A. Ostrander, Elaine; Koutros, Stella; E. Beane Freeman, Laura; J. Stampfer, Meir; Wolk, Alicja; Håkansson, Niclas; L. Andriole, Gerald; N. Hoover, Robert; J. Machiela, Mitchell; D. Sørensen, Karina; Borre, Michael; J. Blot, William; Zheng, Wei; D. Yeboah, Edward; E. Mensah, James; Lu, Yong‐Jie; Zhang, Hongwei; Feng, Ninghan; Mao, Xueying; Wu, Yudong; Zhao, Shan‐Chao; Sun, Zan; N. Thibodeau, Stephen; K. McDonnell, Shannon; J. Schaid, Daniel; West, Catharine; Barnett, Gill; Maier, Christiane; Schnoeller, Thomas; Luedeke, Manuel; S. Kibel, Adam; F. Drake, Bettina; Cussenot, Olivier; Cancel‐Tassin, Géraldine; Ménégaux, F.; Truong, Thérèse; Akoli Koudou, Yves; M. John, Esther; Marie Grindedal, Eli; Mæhle, Lovise; Khaw, Kay-Tee; A. Ingles, Sue; C. Stern, Mariana; Vega, Ana; Gómez‐Caamaño, Antonio; Fachal, Laura; S. Rosenstein, Barry; L. Kerns, Sarah; Ostrer, Harry; R. Teixeira, Manuel; Paulo, Paula; Brandão, Andreia; Watya, Stephen; Lubwama, Alexander; T. Bensen, Jeannette; N. Butler, Eboneé; L. Mohler, James; A. Taylor, Jack; Kogevinas, Manolis; Dierssen-Sotos, Trinidad; Castaño‐Vinyals, Gemma; Cannon‐Albright, Lisa; C. Teerlink, Craig; Huff, Chad; G. Pilié, Patrick; Yu, Yao; J. Bohlender, Ryan; Gu, Jian; S. Strom, Sara; Multigner, Luc; Blanchet, Pascal; Brureau, Laurent; Kaneva, Radka; Slavov, Chavdar; Mitev, Vanio; J. Leach, Robin; Brenner, Hermann; Chen, Xuechen; Holleczek, Bernd; Schöttker, Ben; A. Klein, Eric; W. Hsing, Ann; A. Kittles, Rick; B. Murphy, Adam; J. Logothetis, Christopher; Kim, Jeri; L. Neuhausen, Susan; Steele, Linda; Chun Ding, Yuan; B. Isaacs, William; Nemesure, Barbara; J. M. Hennis, Anselm; D. Carpten, John; Pandha, Hardev; Michael, Agnieszka; De Ruyck, Kim; De Meerleer, Gert; Ost, Piet; Xu, Jianfeng; Hassan Abdul Razack, Azad; Lim, Jasmine; Teo, Soo‐Hwang; F. Newcomb, Lisa; Lin, Daniel; H. Fowke, Jay; M. Neslund-Dudas, Christine; A. Rybicki, Benjamin; Gamulin, Marija; Lessel, Davor; Kuliš, Tomislav; Usmani, Nawaid; Abraham, Aswin; K. Singhal, Sandeep; Parliament, Matthew; Claessens, Frank; Joniau, Steven; Van den Broeck, Thomas; Gago-Domínguez, Manuela; E. Castelao, Jose; Elena Martinez, Maria; Larkin, Samantha; A. Townsend, Paul; Aukim-Hastie, Claire; S. Bush, William; C. Aldrich, Melinda; C. Crawford, Dana; Srivastava, Shiv; Cullen, Jennifer; Petrovics, György; Casey, Graham; Wang, Ying; Tettey, Yao; Lachance, Joseph; Tang, Wei; Biritwum, Richard; A. Adjei, Andrew; Tay, Evelyn; Truelove, Ann; Niwa, Shelley; Yamoah, Kosj; Govindasami, Koveela; P. Chokkalingam, Anand; M. Keaton, Jacob; N. Hellwege, Jacklyn; E. Clark, Peter; Jalloh, Mohamed; Maguèye Gueye, Sérigne; Niang, Lamine; J. Ogunbiyi, Olufemi; Shittu, Olayiwola; K. Amodu, Olukemi; O. Adebiyi, Akindele; I. Aisuodionoe-Shadrach, Oseremen; O. Ajibola, Hafees; A. Jamda, Mustapha; P. Oluwole, Olabode; Nwegbu, Maxwell; Adusei, Ben; Mante, Sunny; O.D. Abrahams, Afua; Diop‐Ndiaye, Halimatou; Gundell, Susan; J. Roobol, Monique; Jenster, Guido; HN van Schaik, Ron; J. Hu, Jennifer; Sanderson, Maureen; Kachuri, Linda; Varma, Rohit; McKean‐Cowdin, Roberta; Torres, Mina; Preuß, Michael; J. F. Loos, Ruth; Zawistowski, Matthew; Zöllner, Sebastian; Lu, Zeyun; K. Van Den Eeden, Stephen; F. Easton, Douglas; Ambs, Stefan; L. Edwards, Todd; Mägi, Reedik; R. Rebbeck, Timothy; G. Fritsche, Lars; J. Chanock, Stephen; I. Berndt, Sonja; Wiklund, Fredrik; Nakagawa, Hidewaki; S. Witte, John; Michael Gaziano, J.; C. Justice, Amy; Mancuso, Nicholas; Terao, Chikashi; A. Eeles, Rosalind; Kote‐Jarai, Zsofia; Madduri, Ravi; V. Conti, David; A. Haiman, Christopher

doi:10.1038/s41588-023-01534-4

Public

Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants

Published in Nature Genetics • Nov 9, 2023

Authors:

Anqi Wang

Jiayi Shen

Alex A Rodriguez

Abstract

The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls...

Subject

Prostate cancer

Biology

Genome-wide association study

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