Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting

Yisimayi, Ayijiang; Song, Weiliang; Wang, Jing; Jian, Fanchong; Yu, Yuanling; Chen, Xiaosu; Xu, Yanli; Yang, Sijie; Niu, Xiao; Xiao, Tianhe; Wang, Jing; Zhao, Lijuan; Sun, Haiyan; An, Ran; Zhang, Na; Wang, Yao; Wang, Peng; Yu, Lingling; Lv, Zhe; Gu, Qingqing; Shao, Fei; Jin, Ronghua; Shen, Zhongyang; Sunney Xie, Xiaoliang; Wang, Youchun; Cao, Yunlong

doi:10.1038/s41586-023-06753-7

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Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting

Published in Nature • Nov 22, 2023

Authors:

Ayijiang Yisimayi

Weiliang Song

Jing Wang

Abstract

. Vaccination strategies to counter immune imprinting are critically needed. Here we investigated the degree and dynamics of immune imprinting in mouse models and human cohorts, especially focusing on the role of repeated Omicron stimulation. In mice, the efficacy of single Omicron boosting is heavi...

Subject

Imprinting (psychology)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Coronavirus disease 2019 (COVID-19)

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