NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance

Zhang, Wenzhe; Zhang, Rongrong; Wu, Ling; Zhu, Chendi; Zhang, Chuanxin; Xu, Chengpeng; Zhao, Shidou; Liu, Xinchen; Guo, Ting; Lu, Yueshuang; Gao, Zheng; Xiao, Yu; Li, Lei; Chen, Zi‐Jiang; Qin, Yingying; Jiao, Xue

doi:10.1016/j.celrep.2023.113531

Public

NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance

Published in Cell Reports • Dec 1, 2023

Authors:

Wenzhe Zhang

Rongrong Zhang

Ling Wu

Abstract

Oocyte maturation is vital to attain full competence required for fertilization and embryogenesis. NLRP14 is preferentially expressed in mammalian oocytes and early embryos. Yet, the role and molecular mechanism of NLRP14 in oocyte maturation and early embryogenesis are poorly understood, and whethe...

Subject

Oocyte

Biology

Embryogenesis

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