Loss of cohesin regulator PDS5A reveals repressive role of Polycomb loops

Bsteh, Daniel; F. Moussa, Hagar; Michlits, Georg; Yelagandula, Ramesh; Wang, Jingkui; Elling, Ulrich; Bell, Oliver

doi:10.1038/s41467-023-43869-w

Public

Loss of cohesin regulator PDS5A reveals repressive role of Polycomb loops

Published in Nature Communications • Dec 9, 2023

Authors:

Daniel Bsteh

Hagar F. Moussa

Georg Michlits

Abstract

Polycomb Repressive Complexes 1 and 2 (PRC1, PRC2) are conserved epigenetic regulators that promote transcriptional gene silencing. PRC1 and PRC2 converge on shared targets, catalyzing repressive histone modifications. Additionally, a subset of PRC1/PRC2 targets engage in long-range interactions who...

Subject

PRC2

Cohesin

Polycomb-group proteins

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