Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity

J. Aronne, Louis; Sattar, Naveed; B. Horn, Deborah; Bays, Harold; Wharton, Sean; Lin, Wen‐Yuan; N. Ahmad, Nadia; Zhang, Shuyu; Liao, Ran; C. Bunck, Mathijs; Jouravskaya, Irina; A. Murphy, Madhumita; Investigators, SURMOUNT-4; Osvaldo Fretes, Jose; Jimena Coronel, Maria; L Gutnisky, Lucas; Frechtel, Gustavo; Gelersztein, Elizabeth; Aizenberg, Diego; Maldonado, Natacha; Pereira, Márcio; G Santos, Queulla; Calil Salim, Camila; Henrique Santos Canani, Luís; Halpern, Bruno; AT Russo, Luis; Bodart, Joselita; V Neto, Danilo; Augusto, Gustavo; Leite, Silmara; Yang, Yi‐Ching; Lin, Wen-Yuan; Huang, Chien‐Ning; Huang, Kuo‐Chin; Fitz-Patrick, David; HT Pau, Cindy; D. Toth, Phillip; Freeman, G.H.; F Gardner, Donald; Wynne, Alan; Loy, Juan; B. Horn, Deborah; Mehra, Purvi; Layle, Stacey; H. Bergthold, James; de Souza, José; Nadar, Venkatesh; Angulo, G; Cohen, Ken; R. Smith, Timothy; J. Aronne, Louis; G. Vaughn, Michael; Aurora Alcantara-Gonzalez, Altagracia; Forman, Seth; Agaiby, John; Geller, S; J. Fraser, Neil; A. Jenders, Robert; Barbel-Johnson, Kim; K. Mayfield, Ronald; D Vance, Carl; T Prier, Kevin; V. Murray, Alexander; Lillestol, Michael; Denham, Douglas; Park, Jean; Klein, E.; Bays, Harold; Philis‐Tsimikas, Athena; E Bressler, Peter; C.H. Reed, John; Aslam, Shamaila; Rosenstock, Julio; P. Frías, Juan; J. Klaff, Leslie; Brazg, Ronald; Gomez-Cuellar, Martha; Connery, Lisa; Van, Joanna; Sélam, Jean-Louis; Kim, John; Blake, Dwight; Gabriel, John; Arora, Samir; J McCartney, Michael; Keith Solano, Royce; K Brodie, Steven; Nardandrea, John

doi:10.1001/jama.2023.24945

Public

Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity

Published in JAMA • Dec 11, 2023

Authors:

Louis J. Aronne

Naveed Sattar

Deborah B. Horn

Abstract

Importance: The effect of continued treatment with tirzepatide on maintaining initial weight reduction is unknown. Objective: To assess the effect of tirzepatide, with diet and physical activity, on the maintenance of weight reduction. Design, Setting, and Participants: This phase 3, randomized with...

Subject

Medicine

Weight loss

Placebo

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