Autophagy of OTUD5 destabilizes GPX4 to confer ferroptosis-dependent kidney injury

Chu, Likai; Cao, Xu; Wan, Lin; Diao, Qiang; Zhu, Yu; Yu, Kan; Ye, Lili; Mao, Yiming; Dong, Xingqiang; Xiong, Qianwei; Fu, Mingcui; Zhang, Ting; Zhou, Huiting; Cai, Shizhong; Ma, Zhou-rui; Hsu, Ssu‐Wei; Wu, Reen; Chen, Ching‐Hsien; Yan, Xiangming; Liu, Jun

doi:10.1038/s41467-023-44228-5

Public

Autophagy of OTUD5 destabilizes GPX4 to confer ferroptosis-dependent kidney injury

Published in Nature Communications • Dec 18, 2023

Authors:

Likai Chu

Xu Cao

Lin Wan

Abstract

Ferroptosis is an iron-dependent programmed cell death associated with severe kidney diseases, linked to decreased glutathione peroxidase 4 (GPX4). However, the spatial distribution of renal GPX4-mediated ferroptosis and the molecular events causing GPX4 reduction during ischemia-reperfusion (I/R) r...

Subject

GPX4

Autophagy

Programmed cell death

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