Obesity Variants in the GIPR Gene Are not Associated With Risk of Fracture or Bone Mineral Density.

Styrkarsdottir, Unnur; Tragante, Vinicius; Stefansdottir, Lilja; Thorleifsson, Gudmar; Oddsson, Asmundur; Sørensen, Erik; Erikstrup, Christian; Schwarz, Peter; Løvendahl Jørgensen, Henrik; Bruun Lauritzen, Jes; Brunak, Søren; U Knowlton, Kirk; D Nadauld, Lincoln; Ullum, Henrik; Birger Vesterager Pedersen, Ole; Rye Ostrowski, Sisse; Holm, Hilma; F Gudbjartsson, Daniel; Sulem, Patrick; Stefansson, Kari

doi:10.1210/clinem/dgad734

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Obesity Variants in the GIPR Gene Are not Associated With Risk of Fracture or Bone Mineral Density.

Shared by NobleBlocks on Jul 12, 2024 • 12:00 AM UTC

Authors:

Unnur Styrkarsdottir

Vinicius Tragante

Lilja Stefansdottir

Abstract

CONTEXT: It is not clear if antagonizing the GIP (glucose-dependent insulinotropic polypeptide) receptor (GIPR) for treatment of obesity is likely to increase the risk of fractures, or to lower bone mineral density (BMD) beyond what is expected with rapid weight loss. OBJECTIVE: The objective of thi...

Subject

BMF

GIP

GIPR

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