Blood DNA methylomic signatures associated with CSF biomarkers of Alzheimer’s disease in the EMIF‐AD Multimodal Biomarker Discovery study

G. Smith, Rebecca; Imm, Jennifer; Dobričić, Valerija; Sommerer, Yasmine; Bos, Isabelle; J. B. Vos, Stephanie; R.J. Verhey, Frans; Scheltens, Philip; Engelborgs, Sebastiaan; B. Frisoni, Giovanni; Blin, Olivier; Richardson, Jill; Bordet, Régis; Tsolaki, Magda; Popp, Julius; Martínez‐Lage, Pablo; Lleó, Alberto; Johannsen, Peter; Freund‐Levi, Yvonne; Lutz, Frölich; Vandenberghe, Rik; Wittig, Michael; Frank, Andre; Lovestone, Simon; Streffer, Johannes; Andréasson, Ulf; Blennow, Kaj; Jelle Visser, Pieter; Zetterberg, Henrik; Bertram, Lars; Lunnon, Katie

doi:10.1002/alz.080072

Public

Blood DNA methylomic signatures associated with CSF biomarkers of Alzheimer’s disease in the EMIF‐AD Multimodal Biomarker Discovery study

Published in Alzheimer s & Dementia • Dec 1, 2023

Authors:

Rebecca G. Smith

Jennifer Imm

Valerija Dobričić

Abstract

Abstract Background The aim of this study was to identify DNA methylation signatures that were associated with 15 CSF biomarker measures of Alzheimer’s disease (AD) or neurodegeneration. Method We profiled DNA methylation in 886 blood samples from the EMIF‐AD study using the Illumina EPIC array, ide...

Subject

Biomarker

DNA methylation

Neurogranin

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