Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation

Mao, Yun-Zi; Zhang, Jiaojiao; Zhou, Qian; He, Xiadi; Zheng, Zhifang; Wei, Yun; Zhou, Kaiqiang; Lin, Yan; Yu, Haowen; Zhang, Haihui; Zhou, Yineng; Lin, Pengcheng; Wu, Baixing; Yuan, Yiyuan; Zhao, Jian‐Yuan; Xu, Wei; Zhao, Shimin

doi:10.1038/s41422-023-00864-6

Public

Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation

Published in Cell Research • Jan 2, 2024

Authors:

Yun-Zi Mao

Jiaojiao Zhang

Qian Zhou

Abstract

Oxidative phosphorylation (OXPHOS) consumes oxygen to produce ATP. However, the mechanism that balances OXPHOS activity and intracellular oxygen availability remains elusive. Here, we report that mitochondrial protein lactylation is induced by intracellular hypoxia to constrain OXPHOS. We show that ...

Subject

Oxidative phosphorylation

Mitochondrion

Biochemistry

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