Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles

M. Tijms, Betty; M. Vromen, Eleonora; Mjaavatten, Olav; Holstege, Henne; M. Reus, Lianne; J. van der Lee, Sven; E. J. Wesenhagen, Kirsten; Lorenzini, Luigi; Vermunt, Lisa; Venkatraghavan, Vikram; Tesi, Niccoló; Tomassen, Jori; den Braber, Anouk; Goossens, Julie; Vanmechelen, Eugeen; Barkhof, Frederik; A.L. Pijnenburg, Yolande; M. van der Flier, Wiesje; E. Teunissen, Charlotte; S. Berven, Frode; Jelle Visser, Pieter

doi:10.1038/s43587-023-00550-7

Public

Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles

Published in Nature Aging • Jan 9, 2024

Authors:

Betty M. Tijms

Eleonora M. Vromen

Olav Mjaavatten

Abstract

Alzheimer's disease (AD) is heterogenous at the molecular level. Understanding this heterogeneity is critical for AD drug development. Here we define AD molecular subtypes using mass spectrometry proteomics in cerebrospinal fluid, based on 1,058 proteins, with different levels in individuals with AD...

Subject

Choroid plexus

Cerebrospinal fluid

Proteomics

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