Design, synthesis, and biological characterization of proteolysis targeting chimera (PROTACs) for the Ataxia telangiectasia and RAD3-related (ATR) kinase

M. Alfayomy, Abdallah; Ashry, Ramy; G. Kansy, Anita; Sarnow, Anne‐Christin; Erdmann, Frank; Schmidt, Matthias; H. Krämer, Oliver; Sippl, Wolfgang

doi:10.26434/chemrxiv-2023-szkt8-v2

Public

Design, synthesis, and biological characterization of proteolysis targeting chimera (PROTACs) for the Ataxia telangiectasia and RAD3-related (ATR) kinase

Published in ChemRxiv • Jan 11, 2024

Authors:

Abdallah M. Alfayomy

Ramy Ashry

Anita G. Kansy

Abstract

The Ataxia telangiectasia and RAD3-related (ATR) kinase is a key regulator of DNA replication stress responses and DNA-damage checkpoints. Several potent and selective ATR inhibitors are reported and four of them are currently in clinical trials in combination with radio- or chemotherapy. Based on t...

Subject

Ataxia-telangiectasia

Kinase

Ubiquitin ligase

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