Early detection of liver injuries by the Serum enhanced binding test sensitive to albumin post-transcriptional modifications.

El Balkhi, Souleiman; Ali Rahali, Mohamad; Lakis, Roy; Ludovic Sauvage, François; Martin, Marving; Janaszkiewicz, Angelika; Lawson, Roland; Goncalves, Ruben; Carrier, Paul; Loustaud-Ratti, Veronique; Guyot, Anne; Marquet, Pierre; Di Meo, Florent; Saint-Marcoux, Franck

doi:10.1038/s41598-024-51412-0

Public

Early detection of liver injuries by the Serum enhanced binding test sensitive to albumin post-transcriptional modifications.

Shared by NobleBlocks on Jan 16, 2024 • 12:00 AM UTC

Authors:

Souleiman El Balkhi

Mohamad Ali Rahali

Roy Lakis

Abstract

Early and sensitive biomarkers of liver dysfunction and drug-induced liver injury (DILI) are still needed, both for patient care and drug development. We developed the Serum Enhanced Binding (SEB) test to reveal post-transcriptional modifications (PTMs) of human serum albumin resulting from hepatocy...

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