Abstract A109: Single-cell epigenomic analysis reveals an important role of the receptor kinase Ror2 in the erosion of cellular identity during pancreatic carcinogenesis

Benitz, Simone; Nasser, Malak; Steep, Alexander; Preall, Jonathan; Mukund Mahajan, Ujjwal; M. Loveless, Ian; T. Davis, Erick; Wen, Hui-Ju; Long, Daniel; Louw, Michaela; D. Zwernik, Samuel; Rempinski, Donald; Moore, Jacee; James Salas-Escabillas, Daniel; J. Metzler, Thomas; Huang, Ling; G. Steele, Nina; Regel, Ivonne; Bednar, Filip; C. Crawford, Howard

doi:10.1158/1538-7445.panca2023-a109

Public

Abstract A109: Single-cell epigenomic analysis reveals an important role of the receptor kinase Ror2 in the erosion of cellular identity during pancreatic carcinogenesis

Published in Cancer Research • Jan 16, 2024

Authors:

Simone Benitz

Malak Nasser

Alexander Steep

Abstract

Abstract Introduction The major driver for pancreatic ductal adenocarcinoma (PDAC) is oncogenic KRAS. However, adult acinar cells, a probable origin of PDAC, are largely refractory to KrasG12D-mediated oncogenic transformation. With the concomitant loss of transcription factors that regulate acinar ...

Subject

PDX1

Biology

Cancer research

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