Ultra-fast label-free quantification and comprehensive proteome coverage with narrow-window data-independent acquisition

H. Guzmán, Ulises; Martínez‐Val, Ana; Ye, Zilu; Damoc, Eugen; N. Arrey, Tabiwang; Pashkova, Anna; Renuse, Santosh; Denisov, Eduard; Petzoldt, J.; C. Peterson, Amelia; Harking, Florian; Østergaard, Ole; Rydbirk, Rasmus; Aznar, Susana; Stewart, Hamish; Xuan, Yue; Hermanson, Daniel; Horning, Stevan; Hock, Christian; Makarov, Alexander; Zabrouskov, Vlad; V. Olsen, Jesper

doi:10.1038/s41587-023-02099-7

Public

Ultra-fast label-free quantification and comprehensive proteome coverage with narrow-window data-independent acquisition

Published in Nature Biotechnology • Feb 1, 2024

Authors:

Ulises H. Guzmán

Ana Martínez‐Val

Zilu Ye

Abstract

Mass spectrometry (MS)-based proteomics aims to characterize comprehensive proteomes in a fast and reproducible manner. Here we present the narrow-window data-independent acquisition (nDIA) strategy consisting of high-resolution MS1 scans with parallel tandem MS (MS/MS) scans of ~200 Hz using 2-Th i...

Subject

Proteome

Mass spectrometry

Quantitative proteomics

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