The Same but Not the Same: The Case of (<i>S</i>)-Naproxen/<i>cis</i>-1-Amino-2-indanol Chiral Resolution via Diastereomeric Salt Formation

Lippi, Martina; Rossi, Patrizia; Ceccarelli, Jacopo; Milazzo, Stella; Morais Missina, Juliana; Ienco, Andrea; Conti, Luca; Chelazzi, Laura; Paoli, Paola

doi:10.1021/acs.cgd.3c01313

Public

The Same but Not the Same: The Case of (S)-Naproxen/cis-1-Amino-2-indanol Chiral Resolution via Diastereomeric Salt Formation

Published in Crystal Growth & Design • Feb 5, 2024

Authors:

Martina Lippi

Patrizia Rossi

Jacopo Ceccarelli

Abstract

The solid state of four novel S -(+)-Naproxen ( S-Nap ) diastereomeric salts with cis -1-amino-2-indanol ( SR-AI and RS-AI enantiomers) is reported. The anhydrous SR-AI_S-Nap_A is the only obtained phase in all the experimental conditions used, while the kinetically preferred diastereomeric salt RS-...

Subject

Diastereomer

Naproxen

Resolution (logic)

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