Successive Protein Extraction Using Hydroxylamine to Increase the Depth of Proteome Coverage in Fresh, Forensic, and Archaeological Bones

Gilbert, Catherine; Bathany, Katell; Claverol, Stéphane; Scanvion, Quentin; Hédouin, Valéry; Bertrand, Benoît; Tokarski, Caroline

doi:10.1021/acs.analchem.3c02803

Public

Successive Protein Extraction Using Hydroxylamine to Increase the Depth of Proteome Coverage in Fresh, Forensic, and Archaeological Bones

Published in Analytical Chemistry • Feb 13, 2024

Authors:

Catherine Gilbert

Katell Bathany

Stéphane Claverol

Abstract

Proteomics is continually being applied to a wider range of applications, now including the analysis of archaeological samples and anatomical specimens, particularly collagen-containing tissues such as bones and teeth. Here, we present the application of a chemical digestion-based proteomics sample ...

Subject

Hydroxylamine

Proteome

Chemistry

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