CD19 CAR T-Cell Therapy in Autoimmune Disease — A Case Series with Follow-up

Müller, Fabian; Taubmann, Jule; Bucci, Laura; Wilhelm, Artur; Bergmann, Christina; Völkl, Simon; Aigner, Michael; Rothe, Tobias; Minopoulou, Ioanna; Tur, Carlo; Knitza, Johannes; Kharboutli, Soraya; Kretschmann, Sascha; Vášová, Ingrid; Spoerl, Silvia; Reimann, Hannah; E. Muñoz, Luis; G. Gerlach, Roman; Schäfer, Simon; Grieshaber‐Bouyer, Ricardo; Korganow, Anne‐Sophie; Farge, Dominique; Mougiakakos, Dimitrios; Bözec, Aline; Winkler, Thomas; Krönke, Gerhard; Mackensen, Andréas; Schett, Georg

doi:10.1056/nejmoa2308917

Public

CD19 CAR T-Cell Therapy in Autoimmune Disease — A Case Series with Follow-up

Published in New England Journal of Medicine • Feb 21, 2024

Authors:

Fabian Müller

Jule Taubmann

Laura Bucci

Abstract

BACKGROUND: Treatment for autoimmune diseases such as systemic lupus erythematosus (SLE), idiopathic inflammatory myositis, and systemic sclerosis often involves long-term immune suppression. Resetting aberrant autoimmunity in these diseases through deep depletion of B cells is a potential strategy ...

Subject

Series (stratigraphy)

Medicine

Disease

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