Efficacy of Spironolactone Compared with Doxycycline in Moderate Acne in Adult Females: Results of the Multicentre, Controlled, Randomized, Double-blind Prospective and Parallel Female Acne Spironolactone vs doxyCycline Efficacy (FASCE) Study

Dréno, Brigitte; Nguyen, Jean‐Michel; Hainaut, E.; Machet, L.; Leccia, M.‐T.; Bénéton, N.; Claudel, Jean-Paul; Celérier, P.; Le Moigne, M.; Le Naour, S.; Vrignaud, Florence; Poinas, Alexandra; Dert, Cécile; Boisrobert, Aurélie; Flet, Laurent; Korner, Simon; Khammari, Amir

doi:10.2340/actadv.v104.26002

Public

Efficacy of Spironolactone Compared with Doxycycline in Moderate Acne in Adult Females: Results of the Multicentre, Controlled, Randomized, Double-blind Prospective and Parallel Female Acne Spironolactone vs doxyCycline Efficacy (FASCE) Study

Published in Acta Dermato Venereologica • Feb 21, 2024

Authors:

Brigitte Dréno

Jean‐Michel Nguyen

E. Hainaut

Abstract

Acne in adult females is triggered mainly by hormones. Doxycycline is a reference treatment in acne. Spironolactone targets the androgen receptor of sebaceous glands and is prescribed off-label for female adult acne. This multicentre, controlled, randomized, double-blind prospective and parallel stu...

Subject

Spironolactone

Acne

Doxycycline

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