A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial

M Noor, Nurulamin; Lee, James; Bond, Simon; Dowling, Francis; Brezina, Biljana; Patel, Kamal; Ahmad, Tariq; Banim, Paul; Berrill, James; Cooney, Rachel; De La Revilla Negro, Juan; de Silva, Shanika; Din, Shahida; Durai, Dharmaraj; Gordon, J; M. Irving, Peter; W. Johnson, Matthew; Kent, Alexandra; Kok, Klaartje; W. Moran, Gordon; Mowat, Craig; Patel, Pritash; Probert, C; Raine, Tim; Saich, Rebecca; Seward, Abigail; Sharpstone, Dan; Smith, Melissa; Subramanian, Sreedhar; Upponi, Sara; A. Wiles, Alan; R. Williams, Horace; R. van den Brink, Gijs; Vermeire, Séverine; Jairath, Vipul; D’Haens, Geert; McKinney, Eoin; Lyons, Paul; O. Lindsay, James; A. Kennedy, Nicholas; G. C. Smith, Kenneth; Parkes, Miles; M Noor, Nurulamin; Lee, James; Bond, Simon; Dowling, Francis; Brezina, Biljana; Patel, Kamal; Ahmad, Tariq; Banim, Paul; Berrill, James; Cooney, Rachel; De La Revilla Negro, Juan; de Silva, Shanika; Din, Shahida; Durai, Dharmaraj; Gordon, J; M. Irving, Peter; W. Johnson, Matthew; Kent, Alexandra; Kok, Klaartje; W. Moran, Gordon; Mowat, Craig; Patel, Pritash; Probert, C; Raine, Tim; Saich, Rebecca; Seward, Abigail; Sharpstone, Dan; Smith, Melissa; Subramanian, Sreedhar; Upponi, Sara; A. Wiles, Alan; R. Williams, Horace; van Den Brink, Gijs; Vermeire, Séverine; Jairath, Vipul; D’Haens, Geert; McKinney, Eoin; Lyons, Paul; O. Lindsay, James; A. Kennedy, Nicholas; G. C. Smith, Kenneth; Parkes, Miles; Allcock, Clare; Bhatti, Suhaylah; Blackwell, Jonathan; Boulton-Jones, Robert; Brookes, Matthew; O. Butcher, Rhys; Butterworth, Jeffrey; Champion, Karlena; Chaudhary, Rakesh; Cole, Andy; Derikx, Lauranne; Dhar, Anjan; Flowerdew, Mary; Goel, Rishi; Hart, Ailsa; Hughes, R; Javaid, Babur; R. Knight, Paul; Lee, Jacinta; W. Lees, Charlie; Levell, Emma; A. Li, Andrew; Murray, Charles; O’Brien, Leisha; Parkes, Gareth; Pollok, Richard; Powles, Sam; Ramdas, Arvind; Smith, Philip; Ally Speight, R.; Travis, Simon; Weaver, Sean; Wesley, Emma

doi:10.1016/s2468-1253(24)00034-7

Public

A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial

Published in The Lancet. Gastroenterology & hepatology • Feb 22, 2024

Authors:

Nurulamin M Noor

James Lee

Simon Bond

Abstract

BACKGROUND: Management strategies and clinical outcomes vary substantially in patients newly diagnosed with Crohn's disease. We evaluated the use of a putative prognostic biomarker to guide therapy by assessing outcomes in patients randomised to either top-down (ie, early combined immunosuppression ...

Subject

Medicine

Crohn's disease

Open label

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