Targeting imidazole-glycerol phosphate dehydratase in plants: novel approach for structural and functional studies, and inhibitor blueprinting

Witek, Wojciech; Śliwiak, Joanna; Rawski, Michał; Ruszkowski, M.

doi:10.3389/fpls.2024.1343980

Public

Targeting imidazole-glycerol phosphate dehydratase in plants: novel approach for structural and functional studies, and inhibitor blueprinting

Published in Frontiers in Plant Science • Mar 15, 2024

Authors:

Wojciech Witek

Joanna Śliwiak

Michał Rawski

Abstract

The histidine biosynthetic pathway (HBP) is targeted for herbicide design with preliminary success only regarding imidazole-glycerol phosphate dehydratase (IGPD, EC 4.2.1.19), or HISN5, as referred to in plants. HISN5 catalyzes the sixth step of the HBP, in which imidazole-glycerol phosphate (IGP) i...

Subject

Isothermal titration calorimetry

Imidazole

Chemistry

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