Disruption of CD47-SIRPα signaling restores inflammatory function in tumor-associated myeloid-derived suppressor cells

Zimarino, Carlo; E. Moody, William; E. Davidson, Sarah; Munir, Hafsa; D. Shields, Jacqueline

doi:10.1016/j.isci.2024.109546

Public

Disruption of CD47-SIRPα signaling restores inflammatory function in tumor-associated myeloid-derived suppressor cells

Published in iScience • Mar 20, 2024

Authors:

Carlo Zimarino

William E. Moody

Sarah E. Davidson

Abstract

Myeloid Derived Suppressor Cells (MDSCs) are a heterogenous immune population with diverse immunosuppressive functions in solid tumours. Here, we explored the role of the tumour microenvironment in regulating MDSC differentiation and immunosuppressive properties via signal-regulatory protein alpha (...

Subject

Myeloid-derived Suppressor Cell

CD47

Function (biology)

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