Fasting upregulates the monocarboxylate transporter MCT1 at the rat blood-brain barrier through PPAR δ activation

Chasseigneaux, Stéphanie; Cochois-Guégan, Véronique; Lecorgne, Lucas; Lochus, Murielle; Nicolic, Sophie; Blugeon, Corinne; Jourdren, Laurent; Gomez‐Zepeda, David; Tenzer, Stefan; Sanquer, Sylvia; Nivet‐Antoine, Valérie; Menet, Marie‐Claude; Laplanche, Jean; Declèves, Xavier; Cisternino, Salvatore; Saubaméa, Bruno

doi:10.1186/s12987-024-00526-8

Public

Fasting upregulates the monocarboxylate transporter MCT1 at the rat blood-brain barrier through PPAR δ activation

Published in Fluids and Barriers of the CNS • Apr 8, 2024

Authors:

Stéphanie Chasseigneaux

Véronique Cochois-Guégan

Lucas Lecorgne

Abstract

BACKGROUND: The blood-brain barrier (BBB) is pivotal for the maintenance of brain homeostasis and it strictly regulates the cerebral transport of a wide range of endogenous compounds and drugs. While fasting is increasingly recognized as a potential therapeutic intervention in neurology and psychiat...

Subject

Blood–brain barrier

Transporter

Monocarboxylate transporter

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