LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells

Cuozzo, Federica; Viloria, Katrina; H. Shilleh, Ali; Nasteska, Daniela; Frazer-Morris, Charlotte; Tong, Jason; Jiao, Zicong; Boufersaoui, Adam; P. Marzullo, Bryan; B. Rosoff, Daniel; Smith, Hannah; Bonner, Caroline; Kerr–Conte, J.; Pattou, François; Nano, Rita; Piemonti, Lorenzo; Johnson, Paul; Spiers, Rebecca; Roberts, Jennie; G. Lavery, Gareth; Clark, Anne; Ceresa, Carlo; Ray, David; Hodson, Leanne; Davies, A.; A. Rutter, Guy; Oshima, Masaya; Scharfmann, Raphaël; J. Merrins, Matthew; Akerman, İldem; A. Tennant, Daniel; Ludwig, Christian; J. Hodson, David

doi:10.1016/j.celrep.2024.114047

Public

LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells

Published in Cell Reports • Apr 1, 2024

Authors:

Federica Cuozzo

Katrina Viloria

Ali H. Shilleh

Abstract

C heteronuclear single quantum coherence NMR spectroscopy, we have obtained a comparative high-resolution map of glucose fate underpinning β cell function. In both mouse and human islets, the contribution of glucose to the tricarboxylic acid (TCA) cycle is similar. Pyruvate fueling of the TCA cycle ...

Subject

Secretion

Basal (medicine)

Endocrinology

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