Gene-expression-based T-Cell-to-Stroma Enrichment (TSE) score predicts response to immune checkpoint inhibitors in urothelial cancer

Rijnders, Maud; Alberto Nakauma-González, J.; G. J. Robbrecht, Debbie; Gil-Jimenez, Alberto; E. Balcioglu, Hayri; A. M. Oostvogels, Astrid; J. B. Aarts, Maureen; L. Boormans, Joost; Hamberg, Paul; S. van der Heijden, Michiel; E. Szabados, Bernadett; J. L. H. van Leenders, Geert; Mehra, Niven; Voortman, Jens; M. Westgeest, Hans; de Wit, Ronald; A. M. van der Veldt, Astrid; Debets, Reno; P. Lolkema, Martijn

doi:10.1038/s41467-024-45714-0

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Gene-expression-based T-Cell-to-Stroma Enrichment (TSE) score predicts response to immune checkpoint inhibitors in urothelial cancer

Shared by NobleBlocks on Feb 14, 2024 • 12:00 AM UTC

Authors:

Maud Rijnders

J. Alberto Nakauma-González

Debbie G. J. Robbrecht

Abstract

Abstract Immune checkpoint inhibitors (ICI) improve overall survival in patients with metastatic urothelial cancer (mUC), but therapeutic success at the individual patient level varies significantly. Here we identify predictive markers of response, based on whole-genome DNA (n = 70) and RNA-sequenci...

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