Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

M. Nievergelt, Caroline; X. Maihofer, Adam; G. Atkinson, Elizabeth; Chen, Chia‐Yen; W. Choi, Karmel; R. I. Coleman, Jonathan; P. Daskalakis, Nikolaos; E. Duncan, Laramie; Polimanti, Renato; Aaronson, Cindy; B. Amstadter, Ananda; Bo Andersen, Søren; A. Andreassen, Ole; A. Arbisi, Paul; E. Ashley‐Koch, Allison; Bryn Austin, S.; Avdibegović, Esmina; Babić, Dragan; Bacanu, Silviu‐Alin; G. Baker, Dewleen; Batzler, Anthony; C. Beckham, Jean; Belangero, Síntia; Benjet, Corina; Bergner, Carisa; M. Bierer, Linda; M. Biernacka, Joanna; J. Bierut, Laura; I. Bisson, Jonathan; P. Boks, Marco; Bolger, Elizabeth; Brandolino, Amber; Breen, Gerome; A. Bressan, Rodrigo; A. Bryant, Richard; C. Bustamante, Angela; Bybjerg‐Grauholm, Jonas; Bækvad‐Hansen, Marie; D. Børglum, Anders; Børte, Sigrid; Cahn, Leah; R. Calabrese, Joseph; Miguel Caldas‐de‐Almeida, José; Chatzinakos, Chris; Cheema, Sheraz; Clouston, Sean; Colodro‐Conde, Lucía; J. Coombes, Brandon; S. Cruz-Fuentes, Carlos; M. Dale, Anders; Dalvie, Shareefa; K. Davis, Lea; Deckert, Jürgen; L. Delahanty, Douglas; F. Dennis, Michelle; Désarnaud, Frank; P. DiPietro, Christopher; G. Disner, Seth; R. Docherty, Anna; Domschke, Katharina; Dyb, Grete; Džubur Kulenović, Alma; J. Edenberg, Howard; Evans, Alexandra; Fabbri, Chiara; Fani, Negar; A. Farrer, Lindsay; Feder, Adriana; C. Feeny, Norah; D. Flory, Janine; Forbes, David; E. Franz, Carol; Galea, Sandro; E. Garrett, Melanie; Gelaye, Bizu; Gelernter, Joel; Geuze, Elbert; F. Gillespie, Charles; B. Goleva, Slavina; D. Gordon, Scott; Goçi, Afërdita; Ruvolo Grasser, Lana; Guindalini, Camila; Haas, Magali; P. Hagenaars, Saskia; A. Hauser, Michael; C. Heath, Andrew; Hemmings, Sian; Hesselbrock, Victor; B. Hickie, Ian; Hogan, Kelleigh; M. Hougaard, David; Huang, Hailiang; M. Huckins, Laura; Hveem, Kristian; Jakovljević, Miro; Javanbakht, Arash; D. Jenkins, Gregory; Johnson, Jessica; Jones, Ian; Jovanović, Tanja; Karstoft, Karen‐Inge; L. Kaufman, Milissa; L. Kennedy, James; C. Kessler, Ronald; Khan, Alaptagin; A. Kimbrel, Nathan; P. King, Anthony; Koen, Nastassja; Kotov, Roman; R. Kranzler, Henry; Krebs, Kristi; S. Kremen, William; Fen Kuan, Pei; R. Lawford, Bruce; A. M. Lebois, Lauren; Lehto, Kelli; F. Levey, Daniel; F Lewis, C; Liberzon, Israel; D. Linnstaedt, Sarah; W. Logue, Mark; Lori, Adriana; Lu, Yi; J. Luft, Benjamin; K. Lupton, Michelle; J. Luykx, Jurjen; Makotkine, Iouri; L. Maples‐Keller, Jessica; Marchese, Shelby; R. Marmar, Charles; G. Martin, Nicholas; Ariadna Martínez-Levy, Gabriela; McAloney, Kerrie; C. McFarlane, Alexander; A. McLaughlin, Katie; A. McLean, Samuel; E. Medland, Sarah; Mehta, Divya; L. Meyers, Jacquelyn; Michopoulos, Vasiliki; A. Mikita, Elizabeth; Milani, Lili; Milberg, William; W. Miller, Mark; A. Morey, Rajendra; Phillip Morris, C.; Mors, Ole; Bo Mortensen, Preben; S. Mufford, Mary; C. Nelson, Elliot; Nordentoft, Merete; B. Norman, Sonya; R. Nugent, Nicole; O’Donnell, Meaghan; K. Orcutt, Holly; Mário Pan, Pedro; S. Panizzon, Matthew; A. Pathak, Gita; Peters, Edward; L. Peterson, Alan; Peverill, Matthew; H. Pietrzak, Robert; A. Polusny, Melissa; Porjesz, Bernice; Powers, Abigail; Qin, Xuejun; Ratanatharathorn, Andrew; B. Risbrough, Victoria; L. Roberts, Andrea; O. Rothbaum, Alex; O. Rothbaum, Barbara; Roy‐Byrne, Peter; J. Ruggiero, Kenneth; L. Rung, Ariane; Runz, Heiko; P. F. Rutten, Bart; Saenz de Viteri, Stacey; Abrahão Salum, Giovanni; Sampson, Laura; E. Sánchez, Sixto; Santoro, Marcos; Seah, Carina; Seedat, Soraya; S. Seng, Julia; A. Shabalin, Andrey; M. Sheerin, Christina; Silove, Derrick; K. Smith, Alicia; W. Smoller, Jordan; R. Sponheim, Scott; J. Stein, Dan; Øien Stensland, Synne; S. Stevens, Jennifer; A. Sumner, Jennifer; H. Teicher, Martin; K. Thompson, Wesley; K. Tiwari, Arun; Trapido, Edward; Uddin, Monica; J. Ursano, Robert; Valdimarsdóttir, Unnur; Van Hooff, Miranda; Vermetten, Eric; H. Vinkers, Christiaan; Voisey, Joanne; Wang, Yunpeng; Wang, Zhewu; A. Waszczuk, Monika; Weber, Heike; R. Wendt, Frank; Werge, Thomas; A. Williams, Michelle; E. Williamson, Douglas; S. Winsvold, Bendik; Winternitz, Sherry; Wolf, Christiane; J. Wolf, Erika; Xia, Yan; Xiong, Ying; Yehuda, Rachel; A. Young, Keith; McD. Young, Ross; C. Zai, Clement; Zai, Gwyneth; Zervas, Mark; Zhao, Hongyu; A. Zoellner, Lori; Zwart, John‐Anker; A. deRoon‐Cassini, Terri; J.H. van Rooij, Sanne; L. van den Heuvel, Leigh; Study, AURORA; Investigators, FinnGen; All-In Psychiatry, HUNT; B. Stein, Murray; J. Ressler, Kerry; C. Koenen, Karestan

doi:10.1038/s41588-024-01707-9

Public

Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder

Published in Nature Genetics • Apr 18, 2024

Authors:

Caroline M. Nievergelt

Adam X. Maihofer

Elizabeth G. Atkinson

Abstract

Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association st...

Subject

Genome-wide association study

Biology

Neuroscience

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!