Curcumin-primed olfactory mucosa-derived mesenchymal stem cells mitigate cerebral ischemia/reperfusion injury-induced neuronal PANoptosis by modulating microglial polarization

Lan, Ziwei; Tan, Fengbo; He, Jialin; Liu, Jianyang; Lu, Ming; Hu, Zhiping; Zhuo, Yi; Liu, Junjiang; Tang, Xiangqi; Jiang, Zheng; Lian, Aojie; Chen, Yongheng; Huang, Yan

doi:10.1016/j.phymed.2024.155635

Public

Curcumin-primed olfactory mucosa-derived mesenchymal stem cells mitigate cerebral ischemia/reperfusion injury-induced neuronal PANoptosis by modulating microglial polarization

Published in Phytomedicine • Apr 20, 2024

Authors:

Ziwei Lan

Fengbo Tan

Jialin He

Abstract

BACKGROUND: Cerebral ischemia-reperfusion (I/R) injury often leads to neuronal death through persistent neuroinflammatory responses. Recent research has unveiled a unique inflammatory programmed cell death mode known as PANoptosis. However, direct evidence for PANoptosis in ischemic stroke-induced n...

Subject

Curcumin

Mesenchymal stem cell

Ischemia

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